2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2510
    Parathyroid Hormone (1-34), human, biotinylated
    		Modulator 99.49%
    Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns.
    Parathyroid Hormone (1-34), human, biotinylated
  • HY-P4692
    pTH (1-44) (human)
    pTH (1-44) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (1-44) (human)
  • HY-A0070B
    Liothyronine sodium hydrate
    		Activator
    Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine sodium hydrate
  • HY-147501
    TRβ agonist 3
    		Agonist
    TRβ agonist 3 (Compound 3) is a potent agonist of TRβ. TRβ agonist 3 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 3 is a new potential TRβ-selective thyromimetics.
    TRβ agonist 3
  • HY-P1418
    DPC-AJ1951
    		Agonist
    DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption.
    DPC-AJ1951
  • HY-111442
    GC 14
    		Antagonist
    GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
    GC 14
  • HY-P1252A
    Parathyroid Hormone (1-34), bovine TFA
    		Agonist
    Parathyroid Hormone (1-34), bovine TFA is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
    Parathyroid Hormone (1-34), bovine TFA
  • HY-A0070AS2
    Liothyronine-13C6-1
    		Agonist
    Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine-13C6-1
  • HY-149218
    THR-β agonist 6
    		Agonist
    THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research.
    THR-β agonist 6
  • HY-P3075
    pTH-Related Protein (1-34) (human,mouse,rat)
    pTH-Related Protein (1-34) (human, mouse, rat), a fragment of parathyroid hormone-related protein, is an anabolic agent. pTH-Related Protein (1-34) (human, mouse, rat) can be used for postmenopausal osteoporosis study.
    pTH-Related Protein (1-34) (human,mouse,rat)
  • HY-P4690
    pTH (13-34) (human)
    pTH (13-34) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (13-34) (human)
  • HY-P4818
    Human PTH-(1-31) amide
    Human PTH-(1-31) amide is a PTH analog. Human PTH-(1-31) amide stimulate phosphatidylcholine hydrolysis and stimulates adenylyl cyclase release.
    Human PTH-(1-31) amide
  • HY-108742R
    Abaloparatide (Standard)
    		Activator
    Abaloparatide (Standard) is the analytical standard of Abaloparatide. This product is intended for research and analytical applications. Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis.
    Abaloparatide (Standard)
  • HY-P10078
    pTH (39-84) (human)
    pTH (39-84) (human) is a parathyroid hormone (PTH) C-terminal fragment. pTH (39-84) (human) stimulates osteoclast formation.
    pTH (39-84) (human)
  • HY-P4823
    pTH (1-37) (human)
    pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis.
    pTH (1-37) (human)
  • HY-P3969
    Prepro-TRH-(160-169)
    		Agonist
    Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.
    Prepro-TRH-(160-169)
  • HY-A0070AS1
    Liothyronine-13C9,15N
    Liothyronine-13C9,15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
    Liothyronine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N
  • HY-P0002R
    Protirelin (Standard)
    		Activator
    Protirelin (Standard) is the analytical standard of Protirelin. This product is intended for research and analytical applications. Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
    Protirelin (Standard)
  • HY-P4697
    pTH (44-68) (human)
    pTH (44-68) (human) is apTH ((Human parathyroid hormone) fragment.
    pTH (44-68) (human)
  • HY-114272A
    T4-ATA (S-isomer)
    		99.50%
    T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
    T4-ATA (S-isomer)
Cat. No. Product Name / Synonyms Application Reactivity